RESEARCH UNIT U905 Inserm ROUEN UNIVERSITY
PHYSIOPATHOLOGY AND BIOTHERAPY OF INFLAMMATORY AND AUTOIMMUNE DISEASES
DIRECTOR PROF. OLIVIER BOYER / SECRETARY ANNIE CHAUBE
Research Topics|Composition|Facilities|Activity|Main Contributions|Ten Main Publications|Contact
RESEARCH TOPICS
Immunoregulation
Pathogenesis, diagnosis and biotherapy of inflammatory myopathies
Pathogenesis, diagnosis and biotherapy of rheumatoid arthritis
Pathogenesis, diagnosis and biotherapy of immuno-dermatological diseases
COMPOSITION
23 scientists, professors, engineers, technicians
12 PhD students, 3 Master students
FACILITIES
Flow cytometry and cell sorting
Gene array analysis
Retroviral gene transfer
Animal facility, including transgenesis
ACTIVITY
The Inserm U905 research unit integrated to the IFRMP 23 is dedicated to the study of inflammatory
and autoimmune diseases of the locomotor apparatus and the skin. To this aim, the laboratory develops
a basic research focused on the mechanisms regulating the immune system, in normal and pathological conditions, and a translational research including clinical trials. The team «Pathogenesis and biotherapy
of inflammatory diseases of the locomotor apparatus», in close collaboration with the Rheumatology Department of the Rouen University Hospital, studies the physiological and physiopathological mechanisms regulating autoimmunity through the development of murine models of myositis and rheumatoid arthritis, analyses the immuno-regulatory roles of ectonucleotides and contributes to clinical trials in inflammatory myopathies and rheumatoid arthritis. The team «Pathogenesis and innovative therapies of immuno-dermatological diseases», in collaboration with the Dermatology Department of the Rouen University Hospital and the National Reference Centre for Bullous Skin Autoimmune Diseases, investigates
the physiopathological mechanisms of autoimmune skin diseases and drug allergy, and develops
new therapeutic approaches in immunodermatology through experimental models and clinical trials.
The Inserm U905 is strongly involved in the identification of new biomarkers characterized by proteomic
and transcriptomic analyses and the development of projects based on molecular biotherapies and cell
and gene therapies.
MAIN CONTRIBUTIONS
Discovery of prognosis factors and of markers predictive of the therapeutic response
in rheumatoid arthritis
Development of the 1st antigenspecific transgenic model of muscle autoimmunity and characterization
of the mechanisms of immunological tolerance towards muscle autoantigens
Demonstration of the immunoregulatory role of extracellular nucleotides (ATP, NAD)
Evaluation of new treatments that changed therapeutical strategies in several autoimmune skin diseases
Demonstration of a role for EBV and HHV6 in certain severe forms of drug allergy
TEN MAIN PUBLICATIONS
1. Lartigue A, Courville P, Auquit I et al. Role of TLR9 in antinucleosome and anti-DNA antibody production
in lpr mutationinduced murine lupus. JOURNAL OF IMMUNOLOGY 2006, 177: 1349-1354
2. Mouquet H, Farci S, Joly P et al. A truncated alternative spliced isoform of human desmoglein 1 contains
a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DR1*0102 molecule. JOURNAL OF IMMUNOLOGY 2006, 177: 6517-6526
3. Dimitri D, Benveniste O, Dubourg O et al. Shared blood and muscle CD8+ T-cell expansions in inclusion body myositis. BRAIN 2006, 129: 986-995
4. Lequerré T, Gauthier-Jauneau AC, Bansard C et al. Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis. ARTHRITIS RESEARCH AND THERAPY 2006, 8: R105
5. Joly P, Mouquet H, Roujeau JC et al. A single cycle of rituximab for the treatment of severe pemphigus. NEW ENGLAND JOURNAL OF MEDICINE 2007, 357: 545-552
6. Adriouch S, Hubert S, Pechberty S et al. NAD+ Released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo. JOURNAL OF IMMUNOLOGY 2007, 179: 186-194
7. Goëb V, Dieudé P, Daveau R et al. Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis. RHEUMATOLOGY 2008, 47: 1208-1212
8. Adriouch S, Bannas P, Schwarz N et al. ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. FASEB JOURNAL 2008, 22: 861-869
9. Calbo S, Delagrèverie H, Arnoult C et al. Functional tolerance of CD8+ T cells induced by muscle-specific antigen expression. JOURNAL OF IMMUNOLOGY 2008, 181: 408-417
10. Mouquet H, Musette P, Gougeon ML et al. B-cell depletion immunotherapy in pemphigus: effects
on cellular and humoral immune responses. JOURNAL OF INVESTIGATIVE DERMATOLOGY 2008,
128: 2859-2869
CONTACTS
U905 INSERM - ROUEN UNIVERSITY - Faculty of Medicine & Pharmacy
22 boulevard Gambetta 76183 Rouen cedex, France
Phone 33.2.35.14.82.80
annie.chaube@univ-rouen.fr or olivier.boyer@chu-rouen.fr
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